1. GSE138709

5个肿瘤样本 + 3个邻近的正常组织

数据集链接：GEO Accession viewer (nih.gov)
文章全文链接：https://www.cell.com/action/showPdf?pii=S0092-8674%2819%2931119-5

2. GSE140228

Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma
文章链接：Landscape and Dynamics of Single Immune Cells in Hepatocellular Carcinoma - PubMed (nih.gov)

16个肝癌患者（癌、癌旁、外周血、淋巴结、腹水组织），单细胞测序

GEO数据链接：GEO Accession viewer (nih.gov)

The accession numbers for the sequencing raw data and processed data in this paper are GSA (Genome Sequence Archive in BIG Data Center, Beijing Institute of Genomics, Chinese Academy of Sciences): **HRA000069** and EGA: **EGAS00001003449** respectively
**原始数据（fastq文件）无法下载，需要申请**

3. PRJCA007744

124例肝癌患者：癌、癌旁、外周血共160个样本（79例HCC患者，25例ICC患者和7例CHC患者），单测（1092172个细胞），89个细胞亚群

Liver tumour immune microenvironment subtypes and neutrophil heterogeneity
文章链接：Liver tumour immune microenvironment subtypes and neutrophil heterogeneity - PubMed (nih.gov)

数据无法下载，需要申请
Raw sequencing data reported in this paper have been deposited at the Genome Sequence Archive at the National Genomics Data Center (Beijing, China) under the BioProject ID PRJCA007744. The data deposited and made public are compliant with the regulations of the Ministry of Science and Technology of China. To facilitate the use of our data by the wider research community, we developed an interactive web-based tool (http://meta-cancer.cn:3838/scPLC) for analysing and visualizing our single-cell data.

4. GSE146115

4个HCC肿瘤样本

Clonal evolution in liver cancer at single-cell and single-variant resolution
文章链接：Clonal evolution in liver cancer at single-cell and single-variant resolution - PubMed (nih.gov)

GEO数据链接：GEO Accession viewer (nih.gov)

5. CNSA: CNP0000650

分析了来自18个原发性或早期复发HCC病例的17,000个细胞的转录组

Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma
文章链接：Single-cell landscape of the ecosystem in early-relapse hepatocellular carcinoma - PubMed (nih.gov)

数据可以下载！！

数据下载链接（包括表达矩阵及meta.data信息）：国家基因库核酸序列归档系统（CNSA）FTP公开服务 (cngb.org)

6. GSE156337

212,000个代表人类胎儿、肝细胞癌 (HCC) 和小鼠肝脏细胞的分析揭示了显著的胚胎样的肿瘤微环境重编程

Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinom
文章链接：Onco-fetal Reprogramming of Endothelial Cells Drives Immunosuppressive Macrophages in Hepatocellular Carcinoma

数据可以下载！！

h5ad文件下载链接：Onco-fetal reprogramming of endothelial cells drives immunosuppressive macrophages in Hepatocellular Carcinoma (Sharma et al) - Mendeley Data
三个单细胞测序标准文件下载链接：GEO Accession viewer (nih.gov)

7. GSE125449

来自19名患者的肝癌生物标本的单细胞转录组图谱

Tumor cell biodiversity drives microenvironmental reprogramming in liver cancer
文章链接：https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6801104/pdf/nihms-1539067.pdf

8. GSE98638

对6个肝癌患者的外周血、肿瘤组织、癌旁正常组织分离出的5063个T细胞进行深度单细胞测序，这里的T细胞包括CD4+和CD8+的两种T细胞。

文章链接：Landscape of Infiltrating T Cells in Liver Cancer Revealed by Single-Cell Sequencing

GEO数据链接：GEO Accession viewer (nih.gov)

9. GSE151530

本研究分析了来自 37 名患者的 46 例肝细胞癌（HCC）和肝内胆管癌（iCCA）活检样本，其中7名患者收集了 16 例治疗前后的活检样本。

文章链接：Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma - PubMed (nih.gov)

GEO数据链接：GEO Accession viewer (nih.gov)