6.构建lncRNA-miRNA-mRNA网络揭示AAA中的关键

题目: Construction of lncRNA‑miRNA‑mRNA networks reveals functional lncRNAs in abdominal aortic aneurysm

DOI: 10.3892/etm.2018.6690

数据集: GSE47472, GSE57691

样本:

GSE7084 & Yang et al: 人mRNA
Yang et al: lncRNA
GSE24194: 兔miRNA

分析方法:

DEG: R语言(corrected P-value of <0.05 and |log2 fold‑change (FC)|≥1)
DAVID: GO和KEGG富集分析
StarBase: 构建lncRNA‑miRNA pairs
miRcode, StarBase, Targetscan: 构建miRNA‑mRNA pairs
补充: only downregulated miRNAs and upregulated mRNAs were integrated into the ceRNA network for upregulated lncRNAs
only upregulated miRNAs and downregulated mRNAs were integrated into the ceRNA network fir downregulated lncRNAs

文章数据:

1.各个数据集的DEG热图

2.GO和KEGG富集结果

3.上调lncRNAs的网络

4.下调lncRNAs的网络

5.关键lncRNA‑mRNA‑biological processes subnetwork

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