【文献速览】-Spatially resolved transc

Spatially resolved transcriptomics (SRT) offers the promise of understanding cells and their modes of dysfunction in the context of intact tissues. Technologies for SRT have advanced rapidly with a large number being published in recent years. Diverse methods for SRT produce data at widely varying depth, throughput, accessibility and cost. Many published SRT methods have been demonstrated only in their labs of origin, while others have matured to the point of commercialization and widespread availability. Here we review technologies for SRT, and their application in studies of tumor heterogeneity.
空间解析转录组学(SRT)提供了理解完整组织中细胞及其功能障碍模式的希望。近年来，SRT技术发展迅速，发表了大量论文。不同的SRT方法产生的数据深度、吞吐量、可达性和成本都有很大的不同。许多已发表的SRT方法仅在其最初的实验室中进行了演示，而其他一些方法已经成熟到商业化和广泛可用的地步。在此，我们对SRT技术及其在肿瘤异质性研究中的应用进行综述。